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Absence of association between specific common variants of the obesity-related FTO gene and psychological and behavioral eating disorder phenotypes

机译：肥胖相关的FTO基因的特定常见变异与心理和行为进食障碍表型之间没有关联

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Extensive population-based genome-wide association studies have identified an association between the FTO gene and BMI; however, the mechanism of action is still unknown. To determine whether FTO may influence weight regulation through psychological and behavioral factors, seven single-nucleotide polymorphisms (SNPs) of the FTO gene were genotyped in 1,085 individuals with anorexia nervosa (AN) and 677 healthy weight controls from the international Price Foundation Genetic Studies of Eating Disorders. Each SNP was tested in association with eating disorder phenotypes and measures that have previously been associated with eating behavior pathology: trait anxiety, harm-avoidance, novelty seeking, impulsivity, obsessionality, compulsivity, and concern over mistakes. After appropriate correction for multiple comparisons, no significant associations between individual FTO gene SNPs and eating disorder phenotypes or related eating behavior pathology were identified in cases or controls. Thus, this study found no evidence that FTO gene variants associated with weight regulation in the general population are associated with eating disorder phenotypes in AN participants or matched controls.
机译：广泛的基于人群的全基因组关联研究确定了FTO基因与BMI之间的关联。但是，其作用机理仍然未知。为了确定FTO是否可能通过心理和行为因素影响体重调节，国际价格基金会遗传研究对1085例神经性厌食症（AN）和677名健康体重控制者进行了FTO基因的七个单核苷酸多态性（SNP）基因分型。饮食失调。对每个SNP进行了与饮食失调的表型和饮食习惯相关的测试：特质焦虑，避免伤害，寻求新奇，冲动，痴迷，强迫和对错误的关注。经过适当的校正以进行多次比较后，在病例或对照中未发现个体FTO基因SNP与进食障碍表型或相关进食行为病理之间的显着关联。因此，这项研究没有发现证据表明在普通人群中与体重调节相关的FTO基因变异与AN参与者或相匹配的对照组的进食障碍表型有关。

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